Restylane® KYSSE
Restylane® KYSSE

Restylane® KYSSE

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The first lip filler with XpresHAn Technology™ for natural-looking volume and Kysse-able softness.

Our office is one of the first in Dallas to offer Restylane® Kysse for the lips and fine lip lines. Kysse will temporarily add volume to the lips and help smooth the wrinkles above your mouth.

Restylane® Kysse, FDA approved in May of 2020, is a clear injectable gel composed of hyaluronic acid (HA). HA is a naturally occurring sugar, found in the human body. Restylane® Kysse is crosslinked with BDDE, an ingredient that helps form a network of HA to provide a gel filler that lasts longer.

Restylane® Kysse is injected with an ultrafine needle into your lips to add fullness. HA fillers, including Restylane® Kysse, contain HA that has been modified to last longer in the body than the naturally occurring HA. Restylane® Kysse contains 0.3 % lidocaine to reduce pain during injection.

In the study of Restylane® Kysse, most side effects were mild or moderate in nature and their duration was short lasting (7 days or less). The most common side effects included, but was not limited to, temporary injection site responses such as: redness, tenderness, firmness, swelling, lumps, bruising, discoloration and itching.

More Information
  • First hyaluronic acid (HA) filler specifically indicated for the lips using XpresHAn Technology
  • Clinically proven to last for up to 1 year 
  • High levels of patient satisfaction for people with lips that have changed due to the aging process
  • Natural-looking results for patients with dynamic facial wrinkles

Are there any reasons why I should not receive Restylane Kysse?
Your doctor will ask about your medical history to determine if Restylane Kysse is right for you. Patients
with any of these conditions should not use Restylane Kysse:
• Highly allergic (for example: a history of severe allergic reaction or multiple severe allergies). Use
may result in an allergic reaction.
• If you have previous experience with allergic reactions to HA fillers. Use may result in an allergic
• Allergic to anesthetics, such as lidocaine. Use may result in an allergic reaction.


What precautions should my doctor discuss with me?
• The use of Restylane Kysse where skin sores, pimples, rashes, hives, cysts, or infections are
present should be postponed until healing is complete. Use of Restylane Kysse where these are
present could delay healing or make your skin problems worse.
• As with any injection procedure, you may have a higher risk of bruising or bleeding at the injection
site if you have a bleeding disorder.
• Tell your doctor if you are using St. John’s Wort, high doses of Vitamin E supplements, aspirin, and
other NSAIDs, such as ibuprofen, because these may increase bruising or bleeding at the injection
• Tell your doctor if you are planning other skin therapies such as laser, mechanical or chemical
peeling, microneedling and hair removal after treatment. The use of Restylane Kysse with these
skin therapies may lead to other side effects such as inflammation.
• After treatment with Restylane Kysse, you should minimize exposure to the sun and avoid being in
the heat and cold until any redness or swelling has disappeared. Exposure to any of these may
cause temporary redness, swelling, and/or itching at the injection site.
• Tell your doctor if you are pregnant or breastfeeding. The safety and effectiveness of Restylane
Kysse has not been established in pregnant women or nursing mothers.
• Tell your doctor if you are on a therapy to decrease the body’s immune response. Treatment may
result in an increased risk of infection.
• Tell your doctor if you have a history of thick, hard scars (excessive scarring). The safety and
effectiveness of Restylane Kysse in patients with a history of thick, hard scars has not been studied
and may result in additional scarring.


What side effects were seen in the clinical study?
In the study of Restylane Kysse, most side effects were mild or moderate in nature and their duration was
short lasting (7 days or less). The most common side effects included, but was not limited to, temporary
injection site responses such as:
o redness,
o pain/tenderness,
o firmness,
o swelling,
o lumps/bumps,
o bruising,
o itching,
o discoloration.


What happens in the office before the injection?
Note that each doctor may have a unique process for treating patients.
The following is an example of what your doctor may do before the injection procedure.
• Talk to you about your medical history, including questions about prior procedures, surgeries,
illnesses and medications you have taken.
• Talk to you about your desired results for your procedure.
• Examine your face and discuss whether Restylane Kysse is the right treatment for you.
• Review what you should expect during and after the procedure.
• Let you know of any possible side effects that you may experience, and what to do if you
experience these.
• Take photos of the area of your face that will be treated.
Your doctor may also have additional ways of evaluating patients and preparing them for a procedure.


What happens during the procedure?
Your doctor may do the following during your procedure:
• Your skin will be cleansed prior to treatment
• Use a cream or ointment called a topical anesthetic to numb the area where you will receive your
• Your doctor will begin the procedure by giving you the first injection, then pausing to allow the
anesthetic that is part of Restylane Kysse to continue to numb the area around your injection. The
anesthetic part of Restylane Kysse has been shown to significantly reduce the pain and discomfort
that may occur with a dermal filler gel injection.
• Your doctor will continue the injection of Restylane Kysse until the area being treated shows the
desired results.
• After the injection is completed, your doctor may gently massage the area that was treated to
ensure the dermal filler gel is distributed evenly and looks natural.


What other treatments are available to me?
There are other dermal filler gels in the United States that are available to you for treatment. Additionally,
there are alternative treatments such as botulinum toxins, laser therapy and chemical peels for the
treatment of lines and wrinkles. You can discuss these treatments with your doctor to determine which
one is right for you.


When should I call my doctor?
You should call your doctor immediately if you have:
• Changes in your vision
• Signs of a stroke (including sudden difficulty speaking, numbness or weakness in your face, arms,
or legs, difficulty walking, face drooping, severe headache, dizziness, or confusion)
• White appearance of the skin
• Unusual pain during or shortly after treatment.
Be sure to call your doctor if you have:
• Persistent injection site reactions beyond 14 days, as most side effects such as bruising, swelling,
pain, tenderness, redness, and itching will usually go away within one to two weeks
• Blisters or skin sores that recur, which may signal the presence of a herpes infection
• Any signs of infection such as fever, redness that spreads to surrounding areas, drainage,
increasing tenderness or increasing pain that does not go away
8 (8)
• Significant pain away from the injection site
• Any side effect that occurs weeks or months after treatment
• Any other symptoms that cause you concern.


What if I experience a problem?
If you believe that you have experienced a serious problem related to Restylane Kysse you should call your
doctor. Your questions about Restylane Kysse can be personally answered by contacting the Galderma
Laboratories L.P. toll-free call center between 8:00 a.m. and 5:00 p.m. Central Daylight Time, Monday to
through Friday.
Galderma (logo)
Restylane and Galderma are registered trademarks.

Treatment Type Filler, Injectables
Treatment Problem or Condition Perioral Lines, Thin Lips
Skin Type N/A
Size 1 cc syringe
Brand Restylane
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The United States Food and Drug Administration (FDA) has approved Restylane Kysse (Galderma), a hyaluronic acid (HA) filler for the lips and upper perioral rhytids in adults over 21 years old. The filler is the first to be equipped with Optimal Balance Technology (OBT) or XpresHAn Technology, which uses advanced tissue integration to achieve a more natural look.

The safety and efficacy of Restylane Kysse has been demonstrated in the Phase 3 trial. Additionally, 78% of patients reported satisfaction with their results after 1 year.1

The most common temporary side effects include masses and nodules, redness, hypersensitivity, bruising and swelling at the injection site.

Restylane® Kysse is the first hyaluronic acid (HA) filler specifically indicated for the lips using XpresHAn Technology™ (pronounced ex-ˈspre-shan') globally referred to as the OBT technology (Optimal Balance Technology).